The beauty landscape is continually transforming, driven by cutting-edge treatments designed to enhance overall skin health.
Amongst these advancements, polynucleotides and hyaluronic acid are gaining considerable attention for their ability to work together effectively. While hyaluronic acid is celebrated for its hydrating qualities, polynucleotides take a different approach—stimulating the body’s own production of hyaluronic acid and reinvigorating fibroblast activity.
As Silvia Bonino, co-founder of Miskonceptions, a skincare brand rooted in science, notes, this synergistic pairing tackles various skin concerns concurrently. “Hyaluronic acid provides immediate hydration,” she explains, “while polynucleotides work on a more profound level to foster lasting skin renewal.”
Polynucleotides are essentially fragments of DNA that actively contribute to skin regeneration while simultaneously boosting the production of collagen and elastin. This process strengthens the skin’s architecture at a cellular level.
According to Bonino, speaking to GB News, “Polynucleotides regenerate fibroblasts, stimulate collagen and elastin synthesis, and enhance overall skin structure—making them particularly effective for addressing deep wrinkles, sagging skin, and atrophic scars.”
Key Differences & Benefits
- Unlike hyaluronic acid’s primary focus on hydration, polynucleotides also actively reduce inflammation.
- This anti-inflammatory action makes them exceptionally well-suited for individuals with conditions like eczema, rosacea, or sensitive skin.
Research published in the Journal of Cosmetic Dermatology last year indicated promising results when polynucleotides are administered via injection, demonstrating improvements in skin texture and a reduction in wrinkles; several studies reported significant outcomes.
The regenerative capabilities of polynucleotides often surpass those of hyaluronic acid alone, particularly for specific issues like:
- Stimulating fibroblast activity—crucial for skin renewal and regeneration.
- Accelerating healing after procedures such as laser treatments or chemical peels by encouraging the formation of new blood vessels.
- Rebalancing melanogenesis, which can help reduce pigmentation concerns and melasma.
- Promoting cellular repair to effectively address scarring, including acne scars and stretch marks.
Bonino emphasizes that while hyaluronic acid excels at hydration and minimizing fine lines, “polynucleotides offer deeper, more enduring regenerative benefits, especially for compromised or aging skin.”
While commonly administered through injections, polynucleotide treatments are also available topically—providing a gentler approach. Scientists suggest the most impactful results may be achieved by combining topical application with enhanced delivery methods, such as microneedling.
As Bonino concludes, “Hyaluronic acid alone is excellent for hydration and fine lines, but polynucleotides offer deeper, long-lasting regenerative benefits, especially for compromised or aging skin.”
